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Wednesday, November 23, 2005
Diagnosis of N2 in NSCLC AND Influenza Vaccination
NCC
・・・やはり現時点では、N2か否かが治療方針決定に重大なポイントとなるような症例では、縦隔鏡を積極的に行うことが重要と考えられる。
コンセンサス癌治療
Lancet 2003
Node activation was more localised after vaccination than after HIV-1 infection. In early and chronic HIV-1 disease, node activation was greater in cervical and axillary than in inguinal and iliac chains (p<0.0001), and summed PET signal correlated with viraemia across a 4 log range (r2=0.98, p<0.0001).
Influenza Vaccination and FDG-PET
We did not generate a complete time-course of node activation, but did show strong signal 3 and 5 days after immunisation. This finding is remarkably consistent with the kinetics of lymphocyte activation and proliferation in well studied mouse
models, in which cells undergo roughly 12 rounds of division within nodes, then
move to the circulation 10–16 days after immunisation. It is also consistent with
the recovery of recently activated lymphocytes in human circulation 14 days after immunisation. This said, there must be some variability among individuals, and
between primary and anamnestic immunisations with regard to onset and
duration of node activation. We want to define these kinetics but have no clear
data at this time. Waiting at least 4 weeks after vaccination before using
PET to diagnose tumour-involved nodes should minimise false positives
from vaccine immunity, but might delay treatment.
Original antigenic sin 1
血清学的交差反応と免疫学的記憶の呼び起こし現象（抗原原罪説）（antigenic recall，original antigenic sin）を誘発することに関して、
Original antigenic sin 2
he phrase 'original antigenic sin' was first used to describe the antibody response to influenza virus. After an initial infection, reinfection (or vaccination) with a new strain of the virus boosted the concentration of antibodies specific for the earlier infecting strain.
・・・やはり現時点では、N2か否かが治療方針決定に重大なポイントとなるような症例では、縦隔鏡を積極的に行うことが重要と考えられる。
コンセンサス癌治療
Lancet 2003
Node activation was more localised after vaccination than after HIV-1 infection. In early and chronic HIV-1 disease, node activation was greater in cervical and axillary than in inguinal and iliac chains (p<0.0001), and summed PET signal correlated with viraemia across a 4 log range (r2=0.98, p<0.0001).
Influenza Vaccination and FDG-PET
We did not generate a complete time-course of node activation, but did show strong signal 3 and 5 days after immunisation. This finding is remarkably consistent with the kinetics of lymphocyte activation and proliferation in well studied mouse
models, in which cells undergo roughly 12 rounds of division within nodes, then
move to the circulation 10–16 days after immunisation. It is also consistent with
the recovery of recently activated lymphocytes in human circulation 14 days after immunisation. This said, there must be some variability among individuals, and
between primary and anamnestic immunisations with regard to onset and
duration of node activation. We want to define these kinetics but have no clear
data at this time. Waiting at least 4 weeks after vaccination before using
PET to diagnose tumour-involved nodes should minimise false positives
from vaccine immunity, but might delay treatment.
Original antigenic sin 1
血清学的交差反応と免疫学的記憶の呼び起こし現象（抗原原罪説）（antigenic recall，original antigenic sin）を誘発することに関して、
Original antigenic sin 2
he phrase 'original antigenic sin' was first used to describe the antibody response to influenza virus. After an initial infection, reinfection (or vaccination) with a new strain of the virus boosted the concentration of antibodies specific for the earlier infecting strain.
Wednesday, November 09, 2005
Memory and Sleep
Sleep-dependent motor memory plasticity in the human brain.
Neuroscience. 2005;133(4):911-7
This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke.
Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation
J Neurosci. 2004 May 12;24(19):4560-7
Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD.
Neuroscience. 2005;133(4):911-7
This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke.
Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation
J Neurosci. 2004 May 12;24(19):4560-7
Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD.
